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Verlag GmbH
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CellTrans Inc
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Journal: Bioinformatics and Biology Insights
Article Title: CellTrans: An R Package to Quantify Stochastic Cell State Transitions
doi: 10.1177/1177932217712241
Figure Lengend Snippet: CellTrans model predictions and validations. (A) to (G) We used CellTrans to analyze data of the evolution of cell state proportions of publicly available data. The data are plotted by colored dots. (A) to (F) The data originate from the work by Gupta et al4 with 3 different cell states (stem, basal, and luminal) from SUM149 and SUM159 breast cancer cell lines. The predictions of our analysis are plotted by colored curves. The color indicates the state of the cells at the beginning of the corresponding experiment. (G) Analysis of composition data (dots) of human mammary epithelial cell lines with cell states CD44−/CD24+ and CD44+/CD24−. The corresponding predictions are plotted as colored curves. (H) to (I) We excluded several of the late data points from the data of the proportions of cancer stem cells (CSCs) and nonstem cancer cells from the work by Yang et al and the data with adherent and suspended cells from the work by Geng et al. The predictions based on the remaining data are plotted, compare also with . This investigation indicates that CellTrans is able to predict cell state proportions even beyond the duration of experiments and that only a few data points are needed to reliably predict the equilibrium.
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